Hikaru Tanaka Selected Research

NIP142

1/2011	Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells.
1/2010	Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization.
1/2007	A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation.
8/2006	Blockade by NIP-142, an antiarrhythmic agent, of carbachol-induced atrial action potential shortening and GIRK1/4 channel.
5/2005	Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractory period and action potential duration in guinea pig myocardium.

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Hikaru Tanaka Research Topics

Disease

6	Cardiac Arrhythmias (Arrythmia) 01/2012 - 05/2005
4	Ischemia 03/2009 - 06/2005
3	Atrial Fibrillation 04/2017 - 05/2005
3	Atrioventricular Block 05/2016 - 02/2007
3	Long QT Syndrome 01/2012 - 02/2007
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2017 - 08/2006
2	Human Influenza (Influenza) 05/2016 - 09/2013
2	Torsades de Pointes (Torsade de Pointes) 05/2016 - 12/2009
2	Esophageal Neoplasms (Esophageal Cancer) 08/2011 - 02/2003
2	Tachycardia (Tachyarrhythmias) 11/2005 - 01/2002
2	Neoplasms (Cancer) 03/2003 - 02/2003
1	Hypoxia (Hypoxemia) 01/2019
1	Atrial Remodeling 02/2018
1	Heart Failure 01/2017
1	Septic Shock (Toxic Shock Syndrome) 01/2017
1	Carcinoma (Carcinomatosis) 02/2016
1	Cardiomyopathies (Cardiomyopathy) 06/2014
1	Diabetes Mellitus 04/2013
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 05/2012
1	Disease Progression 05/2012
1	Autoimmune Diseases (Autoimmune Disease) 05/2012
1	Myocarditis (Carditis) 05/2012
1	Reperfusion Injury 12/2007
1	Contracture 02/2007
1	Atrial Flutter (Flutter, Atrial) 01/2007
1	Barrett Esophagus (Barrett's Esophagus) 07/2003
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 03/2003
1	Stomach Neoplasms (Stomach Cancer) 02/2003
1	Papilloma (Papillomatosis) 01/2002
1	Proteinuria 01/2002
1	Carcinogenesis 01/2002
1	Hyperplasia 01/2002

Drug/Important Bio-Agent (IBA)

5	Pharmaceutical PreparationsIBA 05/2016 - 01/2002
5	NIP142IBA 01/2011 - 05/2005
4	SEA 0400IBA 01/2017 - 06/2005
4	BenzopyransIBA 01/2011 - 05/2005
2	Adenosine Triphosphate (ATP)IBA 01/2019 - 08/2006
2	Cholinergic ReceptorsIBA 02/2018 - 05/2012
2	Oseltamivir (Tamiflu)FDA Link 05/2016 - 09/2013
2	Potassium Channels (Potassium Channel)IBA 01/2011 - 01/2010
2	SolutionsIBA 02/2007 - 08/2006
2	efonidipineIBA 11/2005 - 01/2002
1	KATP ChannelsIBA 01/2019
1	Adrenergic Receptors (Adrenergic Receptor)IBA 04/2017
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 04/2017
1	Indicators and Reagents (Reagents)IBA 01/2017
1	erythromycin propionate-N-acetylcysteinateIBA 01/2017
1	yellow cameleonIBA 01/2017
1	CatecholaminesIBA 01/2017
1	DigitoninIBA 01/2017
1	CytokinesIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 02/2016
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 06/2014
1	Ellagic AcidIBA 04/2013
1	gingerolIBA 04/2013
1	Adenosine Triphosphatases (ATPase)IBA 04/2013
1	AntigensIBA 05/2012
1	AutoantibodiesIBA 05/2012
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 05/2012
1	AntibodiesIBA 05/2012
1	Histamine Antagonists (Antihistamines)IBA 01/2012
1	Diphenhydramine (Benadryl)FDA LinkGeneric 01/2012
1	cloperastineIBA 01/2012
1	clobutinolIBA 12/2009
1	Sodium-Calcium ExchangerIBA 03/2009
1	iberiotoxinIBA 11/2008
1	Charybdotoxin (ChTX)IBA 11/2008
1	salicylhydroxamic acid (SHAM)IBA 11/2008
1	Glyburide (Glibenclamide)FDA LinkGeneric 12/2007
1	Anti-Arrhythmia AgentsIBA 02/2007
1	nifekalantIBA 02/2007
1	Ion Channels (Ion Channel)IBA 01/2007
1	Glucose (Dextrose)FDA LinkGeneric 08/2006
1	1,4-dihydropyridine (dihydropyridine)IBA 11/2005
1	MucinsIBA 07/2003
1	Colloids (Colloid)IBA 02/2003
1	Radioisotopes (Radionuclides)IBA 02/2003
1	TinIBA 02/2003
1	ButylhydroxybutylnitrosamineIBA 01/2002
1	NitrosaminesIBA 01/2002
1	Plant ExtractsIBA 01/2002
1	shosaiko-to (TJ9)IBA 01/2002
1	sairei-toIBA 01/2002
1	Oxygen (Dioxygen)IBA 01/2002

Therapy/Procedure

1	Therapeutics 05/2012
1	Palliative Care (Palliative Therapy) 08/2011
1	Operative Surgical Procedures 11/2008
1	Vagus Nerve Stimulation 01/2007
1	Esophagectomy 03/2003
1	Kampo Medicine (Kampo) 01/2002